ANTI-ADIPOGENESIS
Adipogenesis is the process by which precursor stem cells differentiate into lipid laden adipocytes. Adipogenesis is regulated by a complex and highly orchestrated gene expression program. In mammalian cells, the peroxisome proliferator-activated receptor γ (PPARγ), and the CCAAT/enhancer binding proteins (C/EBPs) such as C/EBPα, β and δ are considered the key early regulators of adipogenesis, while fatty acid binding protein 4 (FABP4), adiponectin, and fatty acid synthase (FAS) are responsible for the formation of mature adipocytes. Excess accumulation of lipids in the adipose tissue leads to obesity, which is associated with cardiovascular diseases, type II diabetes and other pathologies. Thus, investigating adipose tissue development and the underlying molecular mechanisms is vital to develop therapeutic agents capable of curbing the increasing incidence of obesity and related pathologies. Molecular Regulation of Adipogenesis and Potential Anti-Adipogenic Bioactive Molecules - PMC (nih.gov)
In mammalian cells, the peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer binding protein α (C/EBPα) are the main regulators of adipogenesis and have been shown to have a broad overlap in their transcriptional targets [6]. PPARγ is induced during differentiation of preadipocytes to adipocytes and is essential for this process [7]. Without it, precursor cells are unable to differentiate into mature adipocytes [7]. Furthermore, PPARγ is capable of promoting adipogenesis in C/EBPα-deficient cells. However, C/EBPα is not able to promote adipogenesis in PPARγ-deficient cells, demonstrating that PPARγ is the master regulator of adipogenesis. Molecular Regulation of Adipogenesis and Potential Anti-Adipogenic Bioactive Molecules - PMC (nih.gov). The molecular regulation of adipogenesis:
1.) Molecular Regulation of Adipogenesis and Potential Anti-Adipogenic Bioactive Molecules
3.) Molecular Mechanisms of Adipogenesis: The Anti-adipogenic Role of AMP-Activated Protein Kinase