MTOR: THE AGING PATHWAY

1.) mTOR as Regulator of Lifespan, Aging, and Cellular Senescence: A Mini-Review
2.) mTOR activation is a biomarker and a central pathway to autoimmune disorders, cancer , obesity, and Aging
3.) mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells
4.) Molecular damage in cancer : an argument for mTOR -driven Aging
5.) Increased Mammalian Lifespan and a Segmental and Tissue-Specific Slowing of Aging after Genetic Reduction of mTOR Expression
6.) calorie restriction : Decelerating mTOR -driven Aging from cells to organisms (including humans)
7.) mTOR Mediates Wnt-Induced Epidermal Stem Cell Exhaustion and Aging
8.) The proliferation of amplifying neural progenitor cells is impaired in the Aging brain and restored by the mTOR pathway activation
9.) longevity Pathways (mTOR , SIRT, insulin /IGF-1) as Key Modulatory Targets on Aging and Neurodegeneration
10.) mTOR and its link to the picture of Dorian Gray – re-activation of mTOR promotes Aging
11.) From growing to secreting: New roles for mTOR in Aging cells
12.) Mechanistic or mammalian target of rapamycin (mTOR ) may determine robustness in young male mice at the cost of accelerated Aging
13.) M(o)TOR of Aging : mTOR as a universal molecular hypothalamus
14.) Ral and Rheb GTPase Activating Proteins Integrate mTOR and GTPase Signaling in Aging , Autophagy, and Tumor Cell Invasion
15.) mTOR Signaling from Cellular Senescence to Organismal Aging
16.) Potential anti-Aging agents suppress the level of constitutive mTOR – and DNA damage- signaling
17.) Caveolin-1 and Accelerated Host Aging in the Breast Tumor Microenvironment: Chemoprevention with Rapamycin, an mTOR inhibit or and Anti-Aging Drug
18.) mTOR in Aging , metabolism, and cancer
19.) Aberrant mTOR activation in senescence and Aging : A mitochondrial stress response?
20.) Rapalogs and mTOR inhibit ors as anti-Aging therapeutics
21.) Aging and cancer : can mTOR inhibit ors kill two birds with one drug?
22.) Roles of the Raf/MEK/ERK and Pi3k /PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and Aging
23.) mTOR -driven quasi-programmed Aging as a disposable soma theory: Blind watchmaker vs. intelligent designer
24.) BMAL1-dependent regulation of the mTOR signaling pathway delays Aging
25.) Effects of Aging and gender on muscle mass and regulation of Akt-mTOR -p70s6k related signaling in the F344BN rat model
26.) PI3-kinase/Akt/mTOR signaling: Impaired on/off switches in Aging , cognitive decline and Alzheimer’s disease
27.) mTOR inhibit ion: From Aging to Autism and Beyond
28.) mTOR signaling in Aging and neurodegeneration: At the crossroad between metabolism dysfunction and impairment of autophagy
29.) mTOR and autophagy in normal brain Aging and caloric restriction ameliorating age-related cognition deficits
30.) mTOR signalling: the molecular interface connecting metabolic stress, Aging and cardiovascular diseases
31.) Modulating mTOR in Aging and Health